EMS Particular Patient Presentations - Graves' Disease

EMS providers should have an understanding of Graves' Disease and its potential implications for prehospital care. 

Graves' disease is an autoimmune disorder characterized by overactivity of the thyroid gland, leading to hyperthyroidism. This condition is caused by autoantibodies that stimulate the thyroid gland to produce excessive amounts of thyroid hormone.

In terms of prehospital care, EMS providers should be aware of the signs and symptoms of Graves' disease, which may include:

Hyperthyroid Symptoms: Patients with Graves' disease may exhibit symptoms such as rapid heartbeat (tachycardia), palpitations, tremors, heat intolerance, excessive sweating, weight loss despite increased appetite, and fatigue.

Ophthalmic Manifestations: Graves' disease can also cause eye-related symptoms known as Graves' ophthalmopathy or thyroid eye disease. These symptoms may include bulging eyes (exophthalmos), eye irritation, redness, double vision, and vision changes.

Thyroid Gland Enlargement: Some patients with Graves' disease may have a visibly enlarged thyroid gland (goiter) due to thyroid hyperplasia or nodular growth.

Psychological Symptoms: Patients may experience anxiety, irritability, mood swings, and difficulty concentrating due to the effects of excess thyroid hormone on the nervous system.

In terms of potential issues for prehospital care, EMS providers should consider the following:

Cardiovascular Complications: Patients with Graves' disease may be at increased risk of cardiovascular complications such as atrial fibrillation, heart failure, or cardiac arrest due to the effects of excess thyroid hormone on heart function.

Thyroid Storm: In severe cases, Graves' disease can lead to a life-threatening condition known as thyroid storm, characterized by severe hyperthyroidism and systemic decompensation. EMS providers should be prepared to recognize and manage thyroid storm promptly, including supportive measures and administration of medications to control thyroid hormone levels.

Ophthalmic Emergencies: Patients with Graves' ophthalmopathy may present with severe eye symptoms requiring immediate attention, such as corneal ulceration, optic nerve compression, or vision loss. EMS providers should be prepared to provide appropriate eye care and ensure prompt transport to a facility capable of managing ophthalmic emergencies.

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The discovery of Graves' disease is credited to Dr. Robert J. Graves, an Irish physician. 

Dr. Graves first described the condition in 1835 in a paper titled "New Observations on the Diseases of the Thyroid Gland," where he detailed the clinical features of patients with hyperthyroidism associated with goiter and ophthalmic manifestations. 

Dr. Graves' pioneering work laid the groundwork for understanding and diagnosing Graves' disease, and he is recognized as a key figure in the history of endocrinology.

Further Reading:

Alexander, M. & Belle, R. (2017) Advanced EMT: A Clinical Reasoning Approach (2nd Ed). Hoboken, New Jersey: Pearson Education

Bledsoe, B. E., Cherry, R. A. & Porter, R. S (2023) Paramedic Care: Principles and Practice Volume 1 (6th Ed) Pearson.  

Mistovich, J. J. & Karren, K. J. (2014) Prehospital Emergency Care (11th Ed). Hoboken, New Jersey: Pearson Education

EMS Medical Terminology - Cushing's Disease

EMS providers should have a  understanding of Cushing's Disease and its potential implications for prehospital care. 

Cushing's Disease is a condition caused by prolonged exposure to high levels of cortisol, often due to a tumor in the pituitary gland that leads to excessive secretion of adrenocorticotropic hormone (ACTH). This, in turn, stimulates the adrenal glands to produce excess cortisol.

In terms of prehospital care, EMS providers should be aware of the signs and symptoms of Cushing's disease, which may include:

Hypertension: High blood pressure is a common feature of Cushing's disease due to the effects of excess cortisol on blood vessel function.

Weight Gain and Obesity: Patients may exhibit central obesity, particularly in the abdomen, along with increased fat deposits in the face (moon face) and neck (buffalo hump).

Muscle Weakness & Wasting: Excess cortisol can lead to muscle weakness and atrophy, which may affect the patient's mobility and ability to cooperate during assessment and treatment.

Skin Changes: Patients with Cushing's disease may have thin, fragile skin that bruises easily. They may also develop stretch marks (striae) on the abdomen, thighs, and breasts.

Glucose intolerance & Diabetes: High cortisol levels can impair glucose metabolism, leading to insulin resistance and, ultimately, diabetes mellitus.

Psychological Symptoms: Patients may experience mood swings, irritability, depression, or cognitive disturbances due to the effects of excess cortisol on the brain.

In terms of potential issues for prehospital care, EMS providers should consider the following:

Cardiovascular Complications: Patients with Cushing's disease may be at increased risk of cardiovascular events such as heart failure, myocardial infarction, or stroke due to hypertension and other metabolic disturbances.

Fluid & Electrolyte Imbalances: Excess cortisol can disrupt fluid and electrolyte balance, leading to conditions such as hypokalemia (low potassium levels) or hypernatremia (high sodium levels).

Adrenal Crisis: In some cases, abrupt withdrawal of cortisol due to treatment or other factors can precipitate an adrenal crisis characterized by hypotension, dehydration, and shock. EMS providers should be prepared to recognize and manage adrenal crisis promptly.

Communication Challenges: Patients with Cushing's disease may have physical or cognitive impairments that affect their ability to communicate effectively. EMS providers should employ clear communication techniques and be patient and empathetic when interacting with these patients.

Who Made The Dicovery?

The discovery of Cushing's disease is credited to Dr. Harvey Cushing, an American neurosurgeon. Dr. Cushing first described the condition in 1912 in a detailed report titled "The Pituitary Body and its Disorders: Clinical States Produced by Disorders of the Hypophysis Cerebri." 

In this seminal work, he provided comprehensive observations of patients with pituitary tumors, including those exhibiting symptoms of hypercortisolism, now recognized as Cushing's disease. 

Dr. Cushing's pioneering research laid the foundation for understanding and diagnosing this disorder, and he is regarded as a key figure in the history of endocrinology and neurosurgery. This is an example of an eponymous medical term.

Further Reading:

Alexander, M. & Belle, R. (2017) Advanced EMT: A Clinical Reasoning Approach (2nd Ed). Hoboken, New Jersey: Pearson Education

Bledsoe, B. E., Cherry, R. A. & Porter, R. S (2023) Paramedic Care: Principles and Practice Volume 1 (6th Ed) Pearson.  

Mistovich, J. J. & Karren, K. J. (2014) Prehospital Emergency Care (11th Ed). Hoboken, New Jersey: Pearson Education

Peate, I. & Sawyer, S (2024) Fundamentals of Applied Pathophysiology for Paramedics. Hoboken, New Jersey:  Wiley Blackwell